Pre-implantation genetic screening (PGS) is a genetic test that screens all chromosomes of embryos produced through IVF, prior to transfer. Especially among those with increased maternal age, embryos with incorrect number of chromosomes (aneuploid embryos) do not result in a successful pregnancy or cause genetic abnormalities. An embryo with the correct number of chromosomes (euploid embryo) is transferred to the woman’s uterus to implant. If successful, this will result in healthy pregnancy.
Who should go for PGS?
PGS helps couples with:
● Multiple IVF failures
● Recurrent miscarriages
● Congenital diseases like thalassemia, color blindness, spinal dystrophy, etc.
Benefits of PGS
➔ Higher chance of pregnancy
➔ Reduced risk of miscarriage
➔ More confidence in transferring a single embryo
➔ Reduced number of IVF cycles needed to achieve pregnancy
➔ Women of all ages have increased chances of a successful pregnancy
Pre-implantation genetic diagnosis (PGD) is specifically used when one or both parents have known genetic abnormalities.
Who can have PGD?
➢ Those with a history of abortion for previous pregnancies because of a genetic disorder
➢ Couples with an existing child with a genetic condition and want to avoid in future pregnancy
➢ Those with a family history of genetic disorder
Benefits of PGD
PGD helps conceive a pregnancy that is biologically the parent’s own, yet unaffected by genetic conditions in the family. Earlier these parents had to choose adoption, embryo donation, surrogacy or choose not to have children, to avoid the risk of passing on the condition. Several studies have concluded that there are no major side-effects to PGD treatment and babies conceived through this process have the same risks of abnormality than babies conceived through other forms of assisted reproduction.
Oasis is one of the few centres in India to provide PGS and PGD and offer effective treatments for repeated miscarriages, ovulatory dysfunctions, endometriosis, immunological infertility, etc. The experts work closely with couples with different types of assisted fertility treatments and individualise their approach, to best suit every patient.