Facing recurrent implantation failures in three or more consecutive IVF attempts can definitely leave a couple dejected. Such patients need medical and psychological support to cope up with and help them understand what caused it and how they can prevent it from happening again. They evaluate both partners completely and customize the treatment accordingly.
CAUSES AND TREATMENT
Anatomic: The anatomic malformations of the uterus, which are either congenital (septate uterus and bicornuate) or acquired (uterine fibroids, endometrial polyp, intrauterine adhesions and hydrosalpinx), may interfere with normal implantation. Tests like TVS (2D/3D), MRI, hystero laparoscopy help evaluating such abnormalities. Hysteron laparoscopic surgeries can mostly correct the issue.
Endometrium: They implement new techniques to increase the endometrial thickness to 8mm, for a successful implantation, and prepare it for the window of implantation.
Endocrine, blood disorders: Hormonal disorders like thyroid, uncontrolled diabetes and thrombophilia, are diagnosed and treated.
Immunologic factors: The immunological system plays a critical role in implantation, maintenance of pregnancy. Couples who share common HLA alleles may experience recurrent implantation failure. Infusion of 20% intra lipid solutions can address the problem.
Male factors: High DNA fragmentation index in sperm that can cause recurrent miscarriages are treated with medical or surgical modalities with TESA.
Genetic: Recurrent implantation failures due to chromosomal abnormalities transmitted from parents or arising incidentally can be detected by blood test (karyotyping). They offer PGS/PGD to such couples where embryos from IVF are tested for genetic abnormality and only genetically normal embryos are transferred into the uterus. PGS/PGD requires expertise and is available in select fertility centres worldwide. Oasis centre for Reproductive Medicine is one among them. The centre has had its presence for eight years in Hyderabad, apart from branches at Vijayawada and Warangal. Backed by world class facilities, a team of experienced doctors and sensitive management staff, the centre has achieved stellar results in the field of reproductive medicine.