For twelve long years, every positive pregnancy test ended in heartbreak. A 32-year-old woman from Hanumakonda had conceived thrice—only to miscarry at 9, 12, and 24 weeks. Despite multiple treatments, nothing helped her sustain a pregnancy. By the time she arrived at Oasis Fertility, she wasn’t just seeking answers but was running out of hope Unlike conventional approaches that rely on trial and error, Oasis Fertility turned to science, to change the course of her story. A comprehensive evaluation revealed the hidden culprits: Lupus Anticoagulant (50.8 IU/ml), anti-TPO antibodies (54.2 IU/ml), PCOD, and a BMI of 43 — which contributed to implantation failure and pregnancy loss. Instead of following standard protocols, Dr. Kavya Rao Jalagam, Oasis Fertility, Hanumakonda created a personalized treatment metabolic correction— implementing structured lifestyle changes that helped her lower her BMI to 40, significantly improving endometrial receptivity. She underwent an in vitro maturation (IVM) cycle, retrieving 13 oocytes for embryo banking.
With a Progestin-Primed Ovarian Stimulation (PPOS) protocol, 31 oocytes were retrieved, leading to the formation of 18 high-quality blastocysts. To select only the healthiest embryos, Preimplantation Genetic Testing for Aneuploidy (PGT-A) was done. But this wasn’t enough. A detailed Endometrial Receptivity Analysis (ERA) determined the exact implantation window, ensuring the perfect synchronization between the embryo and the uterus. Finally, a single euploid embryo was transferred, supported by a targeted Recurrent Pregnancy Loss (RPL) protocol with proge modulatory therapy. The result was a confirmed healthy pregnancy that progressed safely to 31 weeks—a milestone she had never reached before. SCIENCE- Classic PCOS patients have the highest risk of disrupted oocyte development. They also tend to have more immature oocytes and lower fertilisation rates, partly due to aberrant folliculogenesis, hyperandrogenesm, and intrinsic molecular defects, contributing to lower fertilisation and implantation rates. Additionally, women with PCOS with high BMI tend to have lower oocyte & embryo quality contributing to repeated miscarriages. Hence lifestyle factors, metabolic correction & weight loss can improve oocyte quality & IVF outcomes.
