Magnetic Activated Cell Sorting (MACS)
MACS is a technique that allows the spermatozoa with the best characteristics to be selected for use in Assisted Reproduction Treatments.
All spermatozoa have limited vitality and they cease to exist through a process called Apoptosis. In case, an oocyte is fertilized by Apoptotic Spermatozoa, it is most likely that embryo will be having abnormal development or will stop in its development completely. Such pregnancy usually ends in an early miscarriage.
With the MACS method, we are able to label Apoptotic Spermatozoa, which are then passed through the separation column located inside the magnetic field. Apoptotic Spermatozoa will be retained inside the preparation column.
Living spermatozoa without a sign of Apoptosis will pass through the column with magnetic field and will be collected for later use. ‘Healthy’ sperm can be used for various methods of infertility treatment including IUI, IVF & ICSI.
Embryos created by using these purified spermatozoa have better chance for normal development. MACS technique can be used on all kinds of patients, but is mainly used with:
- Patients who are to be treated with artificial Insemination
- Infertile patients who have a high level of DNA fragmentation in their spermatozoa
- Patients who have had repeated miscarriages with an unidentified cause
- Patients who have had at least one previous treatment cycle or who have poor embryo quality which is not attributable to the oocyte