Pregnancy is Possible Even After Recurrent Miscarriage

Parenthood is a very special journey. For some, it can happen easily within a short span of planning for pregnancy. But for some, the road toward parenthood can be rough and hard. Miscarriage is one such devastating experience for couples. It is very painful physically, emotionally, and psychologically. Recurrent pregnancy loss can shatter one’s trust and faith. But there is hope! Advanced technologies are available that can help couples achieve pregnancy after recurrent miscarriage.  The most important aspect is to visit a fertility specialist if one has experienced recurrent miscarriage.

Advanced Fertility investigations and recurrent miscarriage treatment:

a. Thrombophilia Profile
b. Hysterolaparoscopy
c. Karyotyping
d. PGT (Pre-implantation Genetic Testing)

Thrombophilia profile: 

This test is done to detect any autoimmune condition that can be the cause of recurrent miscarriage. Most common conditions include the presence of antiphospholipid antibodies (APLA), antinuclear antibodies (ANA), anticardiolipin antibodies (ACA), anti-thyroid antibodies (Anti – TPO and anti – TG), etc. The treatment in such conditions includes the usage of steroids, low molecular weight Heparin, iv immunoglobulins, etc.

Hysterolaparoscopy: 

Uterine abnormalities like septate uterus, bicornuate uterus, etc. can be the cause of first and second trimester miscarriages and also preterm birth. Some of these abnormalities might be difficult to diagnose during pregnancy. Hysteroscopic septal resection, metroplasty, surgery for endometriosis, etc. are some of the procedures done to improve the chances of a successful pregnancy.

Karyotyping:

This can help in finding out if there is any genetic disorder in the male or female partner that is the cause of recurrent miscarriage. Any change in the number or structure of chromosomes is an indicator of increased risk of primary or secondary infertility.

Some of the genetic conditions that lead to recurrent pregnancy loss are Y Chromosome Microdeletion, Klinefelter Syndrome, Kallmann Syndrome, etc. Now, how to prevent recurrent pregnancy loss? PGT is the solution.

PGT (Pre-implantation Genetic Testing):

When couples have a genetic disorder, PGT can help in reducing the risk of miscarriage and also prevent the transmission of genetic disorders to their offspring. PGT tests the embryos for genetic abnormalities and only healthy embryos can be selected and implanted in the woman’s uterus. This can increase the possibility of a successful pregnancy along with reducing the risk of transmitting the genetic condition to their progeny.

Types of PGT:

1. PGT – A (Aneuploidy) – Normal number of chromosomes in any human is 46 and it’s called Euploidy. When there is an extra or a low number of chromosomes, it’s called Aneuploidy. PGT-A can check for any extra or missing chromosome. For instance, Down Syndrome, in which there is an extra copy of chromosome 21 can be detected by PGT-A. This can prevent the birth of a child with Down Syndrome.
2. PGT-M (Monogenic) – This is used to detect single-gene disorders like Cystic Fibrosis, Huntington’s disease, etc.
3. PGT-SR (Structural Rearrangements) – Any structural rearrangement in the chromosome can be detected.

PGT helps in detecting many genetic disorders thereby enabling couples to have a healthy pregnancy as well as a healthy baby. The couples need to go for a fertility checkup if they have faced recurrent miscarriage. Never give up hope. Advanced fertility treatments can help you achieve your life’s greatest joy.